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Microarray studies using Affymetrix gene chips have demonstrated GHK-Cu resetting aging-related gene expression profiles in dermal fibroblasts, including upregulation of genes encoding superoxide dismutase (SOD1), metallothionein, collagen types I and III, and multiple anti-inflammatory interleukins

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Second-generation compounds like semaglutide improved on pharmacokinetic profiles, enabling once-weekly dosing and stronger clinical efficacy