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Indeed, there is evidence of mechanistic heterogeneity in the function of zinc transporters across different subtypes of BC
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Cell cycle analysis after 48 h incubation with 100–300 μM demonstrated a dose-dependent cellular accumulation in the G1 phase and apoptosis induction, with (I) caspase-3/7 and PARP activation, (II) reduction in Bcl-2, Bcl-XL, cell cycle progression drivers cyclins D1 and E, and CDK2 and CDK4 protein levels, (III) increased Bax protein levels, (IV) reduced NF-κB p65 nuclear localization, (V) reduction in activation levels of cell growth regulators Akt and STAT3, and (VI) decreased androgen receptor protein levels and activity [86,115,214]