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Pavilion notes

Duotone board — mint brief on the left, coral-folded detail sheet on the right.

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The five subtypes (MC1R to MC5R) are class A G-protein-coupled receptors that signal principally through Gs and adenylyl cyclase to raise intracellular cAMP, and the conserved His-Phe-Arg-Trp core of alpha-MSH is the message sequence recognised by the binding pocket

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