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Drenckhahn a former collaborator of Low continued their joint studies and demonstrated that RBC of patients with unstable, oxidation-sensitive forms of hemoglobin (Heinz body anemia, hemoglobin Köln, and sickle cell anemia) revealed a co-clustering of denatured hemoglobin, of band 3 protein and of RBC-bound immunoglobulins, without having to pretreat RBC with an exogenous oxidizing agent (Schlüter and Drenckhahn, 1986)